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KMID : 0355620120380020121
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2012 Volume.38 No. 2 p.121 ~ p.126
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Genetic aberrations on the short arm of chromosome 8 (8p) in tongue carcinomas
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Murano Akiyuki
Ono Kanae
Koike Hirofumi
Endo Yosuke
Shimada Ken
Kawasaki Kenshi
Nomura Hitomi
Shiiba Masashi
Uzawa Katsuhiro
Tanzawa Hideki
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Abstract
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Aberrations on the short arm of chromosome 8 (8p) are frequently observed in several human cancers. In this study, 20 squamous cell carcinoma (SCC) specimens from the tongue were examined in order to evaluate the role of 8p in SCC of the tongue. Microsatellite analysis using 14 markers demonstrated two commonly deleted regions (CDRs) on 8p. Reverse transcription-polymerase chain reaction (RT-PCR) revealed frequent downregulation of the FEZ1 gene, mapped to 8p22, and frequent over-expression of the cathepsin B gene, mapped to 8p-21-22. These results suggested that genetic aberrations are involved in the development of SCC of the tongue. However, no significant relationship was observed to be established between the genetic alterations and clinicopathological features. Thus, further investigation is necessary in order to clarify the clinical role of 8p in carcinoma of the tongue.
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KEYWORD
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Loss of heterozygosity, Tongue carcinoma, FEZ1 gene, Cathepsin B gene
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